Primary Identifier | MGI:5290070 | Allele Type | Targeted |
Attribute String | Hypomorph | Gene | Smn1 |
Transmission | Germline | Strain of Origin | 129 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exon 7 was replaced with one in which a C to T transition at position 6 of this exon. A floxed pgk-neo selection cassette was inserted about 180 bp distal to exon 7 in the antisense orientation. Analysis of protein expression indicates very low levels of Smn1 and that this is a hypomorphic allele. |