| Primary Identifier | MGI:5295368 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Lrrk2 |
| Transmission | Germline | Strain of Origin | BALB/c |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 41 was replaced with a floxed modified exon 41 with nucleotide substitutions (GGG to TCG) that result in the amino acid substitution of serine for glycine at position 2019 (G2019S), mimicking a mutation found in some late-onset autosomal dominant Parkinson's Disease patients. An FRT-flanked neo cassette inserted downstream of the modified exon 41 was removed by flp-mediated recombination. The predicted protein is kinase enhanced. |
