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Allele : Nkx2-2<tm1Suss> NK2 homeobox 2; targeted mutation 1, Lori Sussel

Primary Identifier	MGI:5297809	Allele Type	Targeted
Attribute String	Null/knockout, RMCE-ready	Gene	Nkx2-2
Transmission	Cell Line	Strain of Origin	129S6/SvEvTac
Is Recombinase	false	Is Wild Type	false

molecularNote

A genomic fragment including exons 1 and 2 was replaced with a pUdeltaTK-EM7kan flanked by heterologous lox sites. This cassette is designed to facilitate recombinase mediated cassette exchange.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
Nkx2.2<LCA>,
Nkx2.2<LCA>

earliestPublication:
Papizan JB, et al. (2011) Nkx2.2 repressor complex regulates islet beta-cell specification and prevents beta-to-alpha-cell reprogramming. Genes Dev 25(21):2291-305

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

6 Publication categories

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