| Primary Identifier | MGI:5297097 | Allele Type | Targeted |
| Attribute String | Hypomorph, Inserted expressed sequence, Modified regulatory region | Gene | Pcdha |
| Transmission | Germline | Strain of Origin | 129 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The diphtheria toxin A gene and a floxed hygro cassette replaced the HS7 (a neuron-specific transcriptional enhancer). A floxed selection cassette was removed by cre-mediated recombination. RT-PCR analysis on whole brain and cerebellum confirmed moderate reduction in transcript expression of all genes in the cluster. However, expression is unaffected in the cortex, hippocampus, and olfactory bulb. |
