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Allele : Tg(Alb-F8*R593C)T4Mcal transgene insertion T4, Michele Calos
Primary Identifier  MGI:5300683 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(Alb-F8*R593C)T4Mcal
Strain of Origin  FVB/N Is Recombinase  false
Is Wild Type  false
molecularNote  The transgene was designed with the murine albumin (Alb) promoter driving expression of human coagulation factor VIII (F8) cDNA. This transgene contains an Arginine to Cysteine missense mutation at amino acid 612 (originally stated as 593), which is prevalent in patients with Hemophilia A.
  • mutations:
  • Insertion
  • synonyms:
  • huFVIII-R593C,
  • huFVIII-R593C
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

4 Publication categories





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