| First Author | Chen WB | Year | 2015 |
| Journal | FEBS Lett | Volume | 589 |
| Issue | 10 | Pages | 1119-26 |
| PubMed ID | 25819439 | Mgi Jnum | J:220821 |
| Mgi Id | MGI:5636529 | Doi | 10.1016/j.febslet.2015.03.015 |
| Citation | Chen WB, et al. (2015) GGPPS deficiency aggravates CCl4-induced liver injury by inducing hepatocyte apoptosis. FEBS Lett 589(10):1119-26 |
| abstractText | GGPPS catalyses the expression of GGPP, a key protein in the mevalonate metabolic pathway. HMG-CoA reductase inhibitor statins can induce liver injury by inhibiting GGPP. However, the function of GGPPS in liver injury has not yet been revealed. In this study, we found that GGPPS increased in liver injury and that GGPPS deletion augmented liver injury and fibrosis. GGPPS inhibition induced hepatocyte apoptosis, inflammation and TGF-beta1 secretion, which activated hepatic stellate cells. Our findings imply that GGPPS deletion induces hepatocyte apoptosis, which makes the liver vulnerable to hepatotoxicity. |
