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Allele : Fgf23<tm1.1Kew> fibroblast growth factor 23; targeted mutation 1.1, Kenneth E White

Primary Identifier  MGI:5305729 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Fgf23
Transmission  Germline Strain of Origin  129
Is Recombinase  false Is Wild Type  false
molecularNote  Exon 3 was replaced with a floxed neo cassette and a modified exon 3 in which a silent mutation inserted a SacI site and a nucleotide substitutions (CGC to CAG) results in the amino acid substitution of glutamine for arginine at position 176 (R176Q), mimicking a mutation found in some autosomal dominant hypophosphatemic rickets (ADHR) patients. Cre-mediated recombination removed the neo cassette.
  • mutations:
  • Insertion,
  • Single point mutation
  • synonyms:
  • Fgf23<R176Q>,
  • ADHR,
  • Fgf23<R176Q>,
  • ADHR
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

7 Publication categories