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Allele : Del(2Lnpk)48Ddu deletion, Chr 2, Denis Duboule 48
Primary Identifier  MGI:5305744 Allele Type  Targeted
Attribute String  Null/knockout Gene  Del(2Lnpk)48Ddu
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  A 240 kb deletion was induced by cre mediated recombination between Is(2)46Ddu and Tg(Hoxd9/lacZ/neo)3Ddu . This region includes the global control region (GCR) and Prox enhancer region that modify expression of the Hoxd genes in the digits. At E12.5 mRNA expression of Hoxd13 was reduced to 60% of wild-type in the developing autopod. Expression of Evx2, Hoxd12, and Hoxd11 was also affected.
  • mutations:
  • Insertion,
  • Intergenic deletion
  • synonyms:
  • Del(2Lnp)48Ddu,
  • Del(rel1-rel5),
  • Del(rel1-rel5),
  • Del(2Lnp)48Ddu
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1 Feature

Genome

0 Expresses

1 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

6 Publication categories





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