| Primary Identifier | MGI:5307922 | Allele Type | Targeted |
| Attribute String | Recombinase | Gene | Tac2 |
| Transmission | Germline | Strain of Origin | 129/Sv |
| Is Recombinase | true | Is Wild Type | false |
| molecularNote | The cre coding sequence with a poly adenylation signal was inserted in-frame with the first ATG of the Tac2 gene by homologous recombination. The initial targeting vector contained an Frt-flanked neomycin cassette. Germline-transmitting mice were crossed with a Flp deleter strain to excise the neo cassette. Insertion of the cre cassette results in generation of a null allele of Tac2 demonstrated by absence of Tac2 expression in the dorsal spinal cord as detected by in situ hybridization. |
