| First Author | Berrien-Elliott MM | Year | 2019 |
| Journal | Immunity | Volume | 51 |
| Issue | 3 | Pages | 479-490.e6 |
| PubMed ID | 31402259 | Mgi Jnum | J:282513 |
| Mgi Id | MGI:6381124 | Doi | 10.1016/j.immuni.2019.06.016 |
| Citation | Berrien-Elliott MM, et al. (2019) MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells. Immunity 51(3):479-490.e6 |
| abstractText | Natural killer (NK) cells are cytotoxic type 1 innate lymphoid cells (ILCs) that defend against viruses and mediate anti-tumor responses, yet mechanisms controlling their development and function remain incompletely understood. We hypothesized that the abundantly expressed microRNA-142 (miR-142) is a critical regulator of type 1 ILC biology. Interleukin-15 (IL-15) signaling induced miR-142 expression, whereas global and ILC-specific miR-142-deficient mice exhibited a cell-intrinsic loss of NK cells. Death of NK cells resulted from diminished IL-15 receptor signaling within miR-142-deficient mice, likely via reduced suppressor of cytokine signaling-1 (Socs1) regulation by miR-142-5p. ILCs persisting in Mir142(-/-) mice demonstrated increased expression of the miR-142-3p target alphaV integrin, which supported their survival. Global miR-142-deficient mice exhibited an expansion of ILC1-like cells concurrent with increased transforming growth factor-beta (TGF-beta) signaling. Further, miR-142-deficient mice had reduced NK-cell-dependent function and increased susceptibility to murine cytomegalovirus (MCMV) infection. Thus, miR-142 critically integrates environmental cues for proper type 1 ILC homeostasis and defense against viral infection. |
