| First Author | Vesela B | Year | 2015 |
| Journal | J Mol Histol | Volume | 46 |
| Issue | 4-5 | Pages | 443-55 |
| PubMed ID | 26253163 | Mgi Jnum | J:316173 |
| Mgi Id | MGI:6832160 | Doi | 10.1007/s10735-015-9636-1 |
| Citation | Vesela B, et al. (2015) Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue. J Mol Histol 46(4-5):443-55 |
| abstractText | Hair follicles are unique organs undergoing regular cycles of proliferation, differentiation, and apoptosis. The final step of apoptosis is, in general, mediated by executioner caspases comprising caspase-3, -6 and -7. Despite their commonly accepted apoptotic function, executioner caspases also participate in non-apoptotic processes. In the present study, we investigated activation (cleavage) of caspase-7 in mouse hair follicles and surrounding tissue during embryonic development into adulthood. Casp7 (-/-) mice were examined to understand the effect of caspase-7 deficiency in the skin. The activated form of caspase-7 was observed during embryonic hair follicle development, as well as in the first hair cycle. In general, activation of caspase-7 did not correlate with apoptosis and activation of caspase-3, except during physiological hair follicle regression. Notably, cleaved caspase-7 was observed in mast cells and its deficiency in the adult skin resulted in increased mast cell number. Our study shows for the first time activated caspase-7 in hair follicles and mast cells and indicates its non-apoptotic roles in the skin. |
