| First Author | Turner SD | Year | 2006 |
| Journal | Anticancer Res | Volume | 26 |
| Issue | 5A | Pages | 3275-9 |
| PubMed ID | 17094440 | Mgi Jnum | J:181238 |
| Mgi Id | MGI:5309153 | Citation | Turner SD, et al. (2006) CD2 promoter regulated nucleophosmin-anaplastic lymphoma kinase in transgenic mice causes B lymphoid malignancy. Anticancer Res 26(5A):3275-9 |
| abstractText | BACKGROUND: Nucleophosmin-anaplastic lymphoma kinase expression is associated with a lymphoid malignancy, anaplastic large cell lymphoma, and is characterized by a t(2;5) chromosomal translocation. MATERIALS AND METHODS: We describe a novel transgenic mouse line in which NPM-ALK expression is targeted to the T-cell lineage using the CD2 promoter. RESULTS: Surprisingly, the mice develop B cell lymphomas in the majority of cases. CONCLUSION: These data stress the importance of choice of promoter to drive transgene expression in obtaining the desired phenotype. |
