| First Author | Julia V | Year | 1996 |
| Journal | Science | Volume | 274 |
| Issue | 5286 | Pages | 421-3 |
| PubMed ID | 8832890 | Mgi Jnum | J:181384 |
| Mgi Id | MGI:5311236 | Doi | 10.1126/science.274.5286.421 |
| Citation | Julia V, et al. (1996) Resistance to Leishmania major induced by tolerance to a single antigen. Science 274(5286):421-3 |
| abstractText | In mice, susceptibility to Leishmania major is associated with the early expansion of T helper 2 cells (TH2) cells, but nothing is known of the specificity of these cells. A previously identified antigen, Leishmania homolog of receptors for activated C kinase (LACK), was found to be the focus of this initial response. Mice made tolerant to LACK by the transgenic expression of the antigen in the thymus exhibited both a diminished TH2 response and a healing phenotype. Thus, T cells that are activated early and are reactive to a single antigen play a pivotal role in directing the immune response to the entire parasite. |
