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Allele : Rr17<tm1.1Cdon> regulatory region 17; targeted mutation 1.1, Chen Dong
Primary Identifier  MGI:5313386 Allele Type  Targeted
Attribute String  Modified regulatory region, Null/knockout Gene  Rr17
Transmission  Germline Strain of Origin  129S6/SvEvTac
Is Recombinase  false Is Wild Type  false
molecularNote  A floxed neo cassette replaced the conserved noncoding sequence 2 (CNS2), located 2 kb upstream of Il17a and 56.5 kb away from Il17f. Cre-mediated recombination removed the neo cassette. ELISA confirmed the reduction in protein expression of Il17a and Il17f in T cells under Th17 conditions.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • CNS2<->,
  • CNS2<->
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories





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