| First Author | Jeon BN | Year | 2019 |
| Journal | FEBS Lett | Volume | 593 |
| Issue | 18 | Pages | 2665-2674 |
| PubMed ID | 31222731 | Mgi Jnum | J:280955 |
| Mgi Id | MGI:6370341 | Doi | 10.1002/1873-3468.13501 |
| Citation | Jeon BN, et al. (2019) Derepression of matrix metalloproteinase gene transcription and an emphysema-like phenotype in transcription factor Zbtb7c knockout mouse lungs. FEBS Lett 593(18):2665-2674 |
| abstractText | Dysregulated matrix metalloproteinase (MMP) gene expression is a major cause of the degradation of lung tissue that is integral to emphysema pathogenesis. Cigarette smoking (CS) increases MMP gene expression, a major contributor to emphysema development. We previously reported that Zbtb7c is a transcriptional repressor of several Mmp genes (Mmps-8, -10, -13, and -16). Here, we show that Zbtb7c knockout mice have mild emphysema-like phenotypes, including alveolar wall destruction, enlarged alveoli, and upregulated Mmp genes. Alveolar size and Mmp gene expression in Zbtb7c(-/-) mouse lungs are increased more severely upon exposure to CS, compared to those of Zbtb7c(+/+) mouse lungs. These observations suggest that Zbtb7c degradation or absence may contribute to the pathogenesis of emphysema. |
