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Allele : Huwe1<tm1.1Mak> HECT, UBA and WWE domain containing 1; targeted mutation 1.1, Tak Mak

Primary Identifier	MGI:5314816	Allele Type	Targeted
Attribute String	Conditional ready, No functional change	Gene	Huwe1
Transmission	Germline	Strain of Origin	129P2/OlaHsd
Is Recombinase	false	Is Wild Type	false

molecularNote

A loxP site was inserted upstream of exon 76. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 77. Flp-mediated recombination removed the neo cassette and left exons 76 and 77 floxed.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
Mule<fl>,
Mule<fl>

earliestPublication:
Hao Z, et al. (2012) The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis. J Exp Med 209(1):173-86

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

2 Carried By

0 Driven By

10 Publication categories

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