| Primary Identifier | MGI:5315475 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Bbs7 |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| description | Phenotypic Similarity to Human Syndrome: Bardet-Biedl Syndrome in mice homozygous for Bbs7tm1Vcs (J:226740) |
| molecularNote | Exon 5 was replaced with a neomycin cassette. This causes a frameshift resulting in a null allele. The absence of expressed transcript was verified by RT-PCR analysis using RNA isolated from homozygous mutant mouse testes with primers within exon 5. The absence of the encoded protein was confirmed by western blotting of homogenates of homozygous mutant mouse testes. |
