| First Author | Wiltschko AB | Year | 2015 |
| Journal | Neuron | Volume | 88 |
| Issue | 6 | Pages | 1121-35 |
| PubMed ID | 26687221 | Mgi Jnum | J:253259 |
| Mgi Id | MGI:6109469 | Doi | 10.1016/j.neuron.2015.11.031 |
| Citation | Wiltschko AB, et al. (2015) Mapping Sub-Second Structure in Mouse Behavior. Neuron 88(6):1121-35 |
| abstractText | Complex animal behaviors are likely built from simpler modules, but their systematic identification in mammals remains a significant challenge. Here we use depth imaging to show that 3D mouse pose dynamics are structured at the sub-second timescale. Computational modeling of these fast dynamics effectively describes mouse behavior as a series of reused and stereotyped modules with defined transition probabilities. We demonstrate this combined 3D imaging and machine learning method can be used to unmask potential strategies employed by the brain to adapt to the environment, to capture both predicted and previously hidden phenotypes caused by genetic or neural manipulations, and to systematically expose the global structure of behavior within an experiment. This work reveals that mouse body language is built from identifiable components and is organized in a predictable fashion; deciphering this language establishes an objective framework for characterizing the influence of environmental cues, genes and neural activity on behavior. |
