| Primary Identifier | MGI:5314788 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Mbp/Prnp)640Zbz |
| Strain of Origin | B6;129S7-Prnp<tm1Cwe> | Is Recombinase | false |
| Is Wild Type | false |
| description | The transgene was generated and maintained in a Prnp-null (Prnptm1Cwe/Prnptm1Cwe) genetic background. (J:97275) |
| molecularNote | The transgene comprises, in order, a 1.3 kb fragment of the mouse myelin basic protein (Mbp) gene that includes the promoter, mRNA cap site and 5' noncoding sequence; a mouse Mbp cDNA containing the full coding sequence for the smallest (14kDa) MBP protein; the 760 bp third exon of the mouse prion protein (Prnp) gene - which contains the entire Prnp open reading frame - flanked by two copies of the rabbit beta-globin second intron; and polyadenylation signals from the rabbit beta-globin and SV40 early region genes. |
