| Primary Identifier | MGI:5319388 | Allele Type | Spontaneous |
| Gene | Dock2 | Strain of Origin | C57BL/6NHsd |
| Is Recombinase | false | Is Wild Type | false |
| description | Dock2mu was confirmed to be present in two Irf5tm1Ttg lines from the USA backcrossed using C57BL/6NHsd but not one line from Japan. J:182658 J:231437 |
| molecularNote | A spontaneous mutation generated a duplication of exons 28 and 29 and frameshift mutation (AAC to TGA) after exon 29. RT-PCR confirmed the reduction in transcript expression in bone marrow cells and splenocytes. This duplication is present in C57BL/6NHsd but not C57BL/6NClr, C57BL/6NJ or C57BL/6NTac. |
