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Allele : Igh<tm4.1Cog> immunoglobulin heavy chain complex; targeted mutation 4.1, Michel Cogne

Primary Identifier	MGI:5320879	Allele Type	Targeted
Gene	Igh	Transmission	Germline
Strain of Origin	129P2/OlaHsd	Is Recombinase	false
Is Wild Type	false

molecularNote

The Mbalpha exon (Calpha membrane exon) was replaced with a loxP site flanked neomycin resistance gene cassette. Cre-mediated recombination removed the neo cassette. ELISA analysis confirmed the reduction in IgA protein expression.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
alphadeltatail,
alphadeltatail

earliestPublication:
Amin R, et al. (2012) Deletion of the alpha immunoglobulin chain membrane-anchoring region reduces but does not abolish IgA secretion. Immunology 136(1):54-63

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

4 Publication categories

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