Primary Identifier | MGI:5320615 | Allele Type | Targeted |
Attribute String | Conditional ready, No functional change | Gene | Hk2 |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A loxP-flanked neomycin resistance (neo) cassette was inserted into intron 3 and a third loxP site into intron 10. The neo cassette was deleted by Cre recombinase in vivo, leaving a single loxP site in intron 3. Crossing mice with this allele to animals expressing Cre recombinase will result in deletion of exons 4-10, inactivating the gene, in the offpring in the tissues or cell types where Cre is expressed. |