| Primary Identifier | MGI:5432932 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Ryr2 |
| Transmission | Germline | Strain of Origin | C57BL/6J |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 43 was replaced with one in which nucleotide substitutions result in the amino acid substitution of serine with leucine at position 2245 in the encoded peptide (p.S2245L), mimicking a mutation found in some catecholaminergic polymorphic ventricular tachycardia patients. The floxed neomycin resistance gene cassette that was inserted into intron 43 was removed by cre-mediated recombination. |
