| First Author | Cariani E | Year | 1991 |
| Journal | J Hepatol | Volume | 13 |
| Issue | 2 | Pages | 220-6 |
| PubMed ID | 1720799 | Mgi Jnum | J:101540 |
| Mgi Id | MGI:3604243 | Doi | 10.1016/0168-8278(91)90818-v |
| Citation | Cariani E, et al. (1991) Insulin-like growth factor II (IGF-II) mRNA expression during hepatocarcinogenesis in transgenic mice. J Hepatol 13(2):220-6 |
| abstractText | Insulin-like growth factor II (IGF-II) mRNA expression is developmentally regulated in liver tissue. We previously observed the reexpression of fetal IGF-II mRNAs in human primary liver cancer and in surrounding cirrhotic tissue. In order to determine the steps of liver cancer progression where the activation of IGF-II fetal mRNAs occurs, we analyzed IGF-II mRNA expression during hepatocarinogenesis in transgenic mice carrying an antithrombin III-SV40 early region hybrid gene. The comparative analysis of mRNAs encoding IGF-II and other differentiation-associated proteins, as well as histological analysis, indicate that the reexpression of fetal IGF-II mRNAs takes place in specific steps of liver cancer progression, both in early pretumorous lesions and in well-differentiated hepatocellular carcinomas. |
