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Allele : Idh1<tm1Mak> isocitrate dehydrogenase 1 (NADP+), soluble; targeted mutation 1, Tak Mak
Primary Identifier  MGI:5438251 Allele Type  Targeted
Attribute String  Conditional ready, Null/knockout Gene  Idh1
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  Arginine codon 132 (CGA) in exon 3 was changed to histidine (CAC) (p.R132H) and a loxP site flanked STOP cassette (puromycin resistance gene, splice acceptor sequence and four copies of SV40 poly(A) signal sequence) was inserted into intron 2. This is a knockout allele and only after Cre-mediated removal of the STOP cassette will it express the mutated transcript and peptide.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • Idh1<LSL>,
  • Idh1<LSL-R132H>,
  • LSL-Idh1R132H,
  • LSL-Idh1R132H,
  • Idh1<LSL>,
  • Idh1<LSL-R132H>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

12 Publication categories





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