| First Author | Bhave S | Year | 2023 |
| Journal | JACC Basic Transl Sci | Volume | 8 |
| Issue | 10 | Pages | 1318-1330 |
| PubMed ID | 38094696 | Mgi Jnum | J:357502 |
| Mgi Id | MGI:7763735 | Doi | 10.1016/j.jacbts.2023.05.017 |
| Citation | Bhave S, et al. (2023) Loss of Bone Morphogenetic Protein-9 Reduces Survival and Increases MMP Activity After Myocardial Infarction. JACC Basic Transl Sci 8(10):1318-1330 |
| abstractText | No studies have explored a functional role for bone morphogenetic protein (BMP)-9, a transforming growth factor-beta superfamily ligand, in cardiac remodeling after myocardial infarction (MI). Using BMP-9 null mice, we observed that loss of BMP-9 decreases survival and increases cardiac rupture after MI. We further observed that loss of BMP-9 not only increases collagen abundance, but also promotes matrix metalloproteinase-9 activity and collagen degradation after MI. These findings identify BMP-9 as a necessary component of cardiac remodeling after MI and a potentially important target of therapy to improve outcomes after MI. |
