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Allele : Odad3<b2b1885Clo> outer dynein arm docking complex subunit 3; Bench to Bassinet Program (B2B/CVDC), mutation 1885 Cecilia Lo
Primary Identifier  MGI:5445347 Allele Type  Chemically induced (ENU)
Gene  Odad3 Strain of Origin  C57BL/6J
Is Recombinase  false Is Wild Type  false
Project Collection  B2B/CvDC
description  Summative Diagnosis:
Cardiac phenotype: Dextrocardia associated with situs inversus totalis
Noncardiac phenotype: Hypoplastic spleen, adrenal anomaly, immotile/dyskinetic tracheal airway cilia

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0100 Situs inversus totalis
0110 Dextrocardia
4851 Kartagener syndrome (siewart syndrome)(primary ciliary dyskinesia)

molecularNote  This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is a T to C substitution at nucleotide +2 following coding nucleotide 828 (c.828+2T>C, NM_029939) in intron 6. This changes splice donor site G-GT to G-GC (which is assumed to be less efficient)
  • mutations:
  • Single point mutation
  • synonyms:
  • Snowball,
  • Snowball
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

5 Publication categories





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