| Primary Identifier | MGI:5444645 | Allele Type | Targeted |
| Attribute String | Inducible, Recombinase, Transactivator | Gene | Sftpc |
| Transmission | Germline | Strain of Origin | 129 and C57BL/6 |
| Induced With | tamoxifen | Is Recombinase | true |
| Is Wild Type | false |
| description | Targeting was accomplished in 129/C57bl6 hybrid ES cells (iGeniousTL, Inc., Stony Brook, NY). |
| molecularNote | The terminal stop codonin exon 5 of the endogenous mouse gene was replaced with an estrogen-dependent cre cDNA (creERT2) preceded in frame by a E2A peptide sequence to interrupt translation between SPC and cre mRNAs coexpressed on a single transcript and followed by a T2A peptide sequence and rtTA. This was then followed by an Frt flanked neo selection cassette. |
