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Allele : b2b1430Clo Mutant line 1430; Bench to Bassinet Program (B2B/CVDC), mutation 1430 Cecilia Lo
Primary Identifier  MGI:5446156 Allele Type  Chemically induced (ENU)
Gene  b2b1430Clo Strain of Origin  C57BL/6J
Is Recombinase  false Is Wild Type  false
Project Collection  B2B/CvDC
description  Summative Diagnosis:
Cardiovascular phenotype: Malalignment of the great arteries with transposition of the great arteries (TGA), double outlet right ventricle (DORV), hypoplastic left ventricle, and aortic arch anomalies such as right aortic arch (RAA) and double aortic arch
Noncardiovascular phenotype: Short snout, cleft palate, malaligned sternal vertebra, kidney agenesis, hypoplastic/dysplastic kidney, cystic kidney, and hydronephrosis

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0300 Hypoplastic left heart syndrome
0600 Double outlet right ventricle
0700 D-loop transposition of the great arteries
1811 Hypoplastic left ventricle (subnormal cavity volume)
2700 Abnormal aortic arch
2720 Right aortic arch
2761 Double aortic arch
4100 Skeletal, skin, muscle anomaly
4502 Hydronephrosis
4503 Agenesis of kidneys
4876 Cleft palate
4906 Non-cardiac abnormality
4907 Non-cardiac thoracic abnormality

molecularNote  This ENU-induced mutation was isolated in a screen at the University of Pittsburgh.
  • mutations:
  • Undefined
  • synonyms:
  • Donner,
  • Donner
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

4 Publication categories





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