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Allele : Rr578<em1Krum> regulatory region 578; endonuclease-mediated mutation 1, Robb Krumlauf
Primary Identifier  MGI:7785535 Allele Type  Endonuclease-mediated
Attribute String  Modified regulatory region Gene  Rr578
Is Recombinase  false Is Wild Type  false
molecularNote  The Hoxb enhancer ENE retinoic acid response element (ENE-RARE) was targeted for binding site disruption using an sgRNA (equivalent to GAGGAGGAAGAGTTCATGGAG) and an ssODN template with CRISPR/Cas9 technology, changing it from AGTTCAtggagAGGCCA to ACCAAGtggacTGAATT.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • ENE<->,
  • ENE<->
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

2 Publication categories





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