| Primary Identifier | MGI:5451082 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Phox2b |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| description | ES cell line EB3/5, derived from E14TG2a, carries one allele of Pou5f1 that has been inactivated via targeted integration of E14TG2a ES cells with an IRESBSDpA selection cassette. J:190742 does not mention whether the null allele of Pou5f1 is also present in the line of mice created. |
| molecularNote | Exon 3 was replaced with a modified exon 3 in which nucleotides 693-700 were deleted (693-700 del8), mimicking a deletion found in some human autonomic neurocristopathies. Cre-mediated recombination removed the floxed neo cassette inserted downstream of exon 3. |
