| Primary Identifier | MGI:5463124 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Prnp-TARDBP*M337V)106Dwc |
| Strain of Origin | C57BL/6 x C3H | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A full-length human TAR DNA binding protein (TARDBP or TDP-43) cDNA sequence was modified to have both an N-terminal myc tag and a methionine to valine substitution at amino acid 337. This huTDP-43*M337V cDNA sequence was inserted between exon 2 and exon 3 of mouse prion protein (Prnp) gene. The resulting Prnp-TDP-43*M337V transgene was flanked with loxP sites. Founder line 106 was selected for further characterization. |
