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Allele : Atxn2<tm2.1Aub> ataxin 2; targeted mutation 2.1, Georg Auburger

Primary Identifier	MGI:5467982	Allele Type	Targeted
Attribute String	Humanized sequence	Gene	Atxn2
Transmission	Germline	Strain of Origin	129S2/SvPas
Is Recombinase	false	Is Wild Type	false

molecularNote

Exon 1 was replaced with one in which the CAG trinucleaotide repeat is expanded to 42 copies. Flp-mediated recombination removed the FRT-flanked neo cassette inserted downstream of the modified exon 1.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
Atxn2-CAG42,
Atxn2<tm2.1Geno>,
Atxn2-CAG42,
Atxn2<tm2.1Geno>

earliestPublication:
Damrath E, et al. (2012) ATXN2-CAG42 Sequesters PABPC1 into Insolubility and Induces FBXW8 in Cerebellum of Old Ataxic Knock-In Mice. PLoS Genet 8(8):e1002920

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

2 Carried By

0 Driven By

9 Publication categories

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