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Allele : Dot1l<tm1.1Wezh> DOT1 like histone lysine methyltransferase; targeted mutation 1.1, Wenzheng Zhang

Primary Identifier	MGI:5471952	Allele Type	Targeted
Attribute String	Conditional ready, No functional change	Gene	Dot1l
Transmission	Germline	Strain of Origin	C57BL/6J
Is Recombinase	false	Is Wild Type	false

molecularNote

A loxP site was inserted upstream of exon 5. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette and left exon 5 floxed.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
Dot1l<f>,
Dot1l<f>

earliestPublication:
Chang MJ, et al. (2010) Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes. Cancer Res 70(24):10234-42

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

9 Publication categories

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