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Allele : Igs86<tm1Low> intergenic site 86; targeted mutation 1, Malcolm J Low
Primary Identifier  MGI:5473420 Allele Type  Targeted
Attribute String  Modified isoform(s), Modified regulatory region Gene  Igs86
Transmission  Germline Strain of Origin  129S4/SvJae
Is Recombinase  false Is Wild Type  false
molecularNote  A loxP site flanked neomycin resistance gene cassette was inserted between the first upstream neuronal enhancer (nPE1) and the deleted second neuronal enhancer (nPE2). The pituitary enhancer/promoter is not affected. Immunohistochemistry confirmed the lack of neuronal transcription in the hypothalamic arcuate nucleus (Arc) and normal expression in pituitary cells.
  • mutations:
  • Insertion
  • synonyms:
  • Pomc<NEO>,
  • arcPomc<->,
  • Pomc<NEO>,
  • Pomc<tm2Low>,
  • arcPomc<->,
  • Pomc<tm2Low>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

18 Publication categories





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