| First Author | Lee J | Year | 2016 |
| Journal | Neuron | Volume | 90 |
| Issue | 5 | Pages | 1071-1085 |
| PubMed ID | 27210555 | Mgi Jnum | J:240207 |
| Mgi Id | MGI:5882653 | Doi | 10.1016/j.neuron.2016.05.001 |
| Citation | Lee J, et al. (2016) Linking Cholinergic Interneurons, Synaptic Plasticity, and Behavior during the Extinction of a Cocaine-Context Association. Neuron 90(5):1071-85 |
| abstractText | Despite the fact that cholinergic interneurons are a key cell type within the nucleus accumbens, a relationship between synaptic plasticity and the in vivo activity of cholinergic interneurons remains to be established. Here, we identify a three-way link between the activity of cholinergic interneurons, synaptic plasticity, and learning in mice undergoing the extinction of a cocaine-context association. We found that activity of cholinergic interneurons regulates extinction learning for a cocaine-context association and generates a sustained reduction in glutamatergic presynaptic strength onto medium spiny neurons. Interestingly, activation of cholinergic interneurons does not support reinforcement learning or plasticity by itself, suggesting that these neurons have a modulatory rather than a reinforcing function. |
