Primary Identifier | MGI:5474655 | Allele Type | Targeted |
Attribute String | Hypomorph | Gene | Gabrg2 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The coding region was replaced with a coding region containing substitution that results in an amino acid substution of a glutamine for an arginine at position 43 (R43Q), 4 additional silent mutations (not identified) and a floxed neo cassette. This allele is hypomorphic and was used to generate Gabrg2tm1Spet. QPCR confirms reduced transcript expression at P15 and P66. |