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Allele : Cdkl5<tm1.1Joez> cyclin dependent kinase like 5; targeted mutation 1.1, Zhaolan Zhou

Primary Identifier	MGI:5475468	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Cdkl5
Transmission	Germline	Strain of Origin	129
Is Recombinase	false	Is Wild Type	false

molecularNote

A floxed neo cassette was inserted upstream of exon 6. A loxP site was inserted downstream of exon 6. Cre-mediated recombination removed the neo cassette and exon 6. Western blot analysis confirmed the absence of protein expression.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

earliestPublication:
Wang IT, et al. (2012) Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice. Proc Natl Acad Sci U S A 109(52):21516-21

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

2 Carried By

0 Driven By

16 Publication categories

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