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Allele : Npm1<tm1Hft> nucleophosmin 1; targeted mutation 1, Hwei-Fang Tien
Primary Identifier  MGI:5478640 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Npm1
Transmission  Germline Strain of Origin  129
Is Recombinase  false Is Wild Type  false
molecularNote  Exon 11 was replaced with a floxed neo cassette and a modified exon 11 in which the wild-type sequence is replaced with a TCTG insertion after the coding sequence nucleotide 8657 (c.854_857dupTCTG). This "conventional" mutation mimics the human mutation observed in patients with acute myeloid leukemia (AML;type A, c.860_863dupTCTG) without any "humanized" sequence.
  • mutations:
  • Insertion
  • synonyms:
  • Npm1<c+>,
  • Npm1<c+>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories





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