| Primary Identifier | MGI:5484538 | Allele Type | Targeted |
| Gene | Stk11 | Transmission | Germline |
| Strain of Origin | C57BL/6NTac | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Exon 3 was replaced with a modified exon 3 in which nucleotide substitutions replaces a methionine with glycine at position 129 (M129G). This mutation is expected to disrupt the gatekeeper residue in the ATP-binding pocket possibly rendering the protein susceptible to small molecular analogues of the general kinase inhibitor PP1. Cre-mediated recombination removed the floxed neo cassette inserted downstream of exon 2. Activity assay confirmed the sensitivity to 1NMPP1 inhibition. |
