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Allele : Sppl2a<chompB> signal peptide peptidase like 2A; chompB

Primary Identifier	MGI:5484577	Allele Type	Chemically induced (ENU)
Attribute String	Hypomorph	Gene	Sppl2a
Strain of Origin	C57BL/6	Is Recombinase	false
Is Wild Type	false

molecularNote

ENU mutagenesis induced a T to A transversion that results in the amino acid substitution of lysine for methionine at position 252 (M252K) in the third transmembrane domain. This allele is hypomorphic.

mutations:
Single point mutation

earliestPublication:
Beisner DR, et al. (2013) The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain. J Exp Med 210(1):23-30

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

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