| First Author | Gaynullina D | Year | 2015 |
| Journal | FEBS Lett | Volume | 589 |
| Issue | 10 | Pages | 1164-70 |
| PubMed ID | 25819435 | Mgi Jnum | J:220822 |
| Mgi Id | MGI:5636530 | Doi | 10.1016/j.febslet.2015.03.018 |
| Citation | Gaynullina D, et al. (2015) Pannexin 1 facilitates arterial relaxation via an endothelium-derived hyperpolarization mechanism. FEBS Lett 589(10):1164-70 |
| abstractText | Pannexin 1 (Panx1) is involved in endothelium-dependent vasodilation in large arteries, but the exact mechanistic role remains poorly understood. We hypothesized that Panx1 facilitates large vessel relaxations regulating endothelium-derived hyperpolarization (EDH)-like mechanisms. The EDH-like component of acetylcholine-induced relaxation of saphenous arteries studied in isometric myograph after inhibition of NO-synthase and cyclooxygenase was significantly impaired in mice with genetically ablated Panx1 (KO) relative to that in the wild type (WT) mice. Application of P1-receptor antagonist and apyrase significantly reduced this component in WT, but not in KO mice, indicating participation of ATP released via Panx1 in the EDH-like relaxation. |
