| Primary Identifier | MGI:7265153 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Bard1 |
| Transmission | Germline | Strain of Origin | (C57BL/6J x 129S6/SvEvTac)F1 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | : The targeting vector contains a loxP-flanked neomycin inserted into intron 6 and an aspartic acid to histidine amino acid substitution at position 488 (D488H; GAT to CAT) inserted into exon 6. Cre-mediated recombination removed the neomycin cassette.The mutation corresponds to human tumor-associated missense mutations in the ankyrin domain that disrupts BARD1 recognition of H4K20me0 (histone H4 unmethylated at lysine 20). |
