| Primary Identifier | MGI:5484766 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(LCR-HBA1,LCR-HBB*)1Tow |
| Strain of Origin | (C57BL/6 x SJL)F1 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Two transgenes were designed to each be controlled independently by five upstream sites (HS I-V) of the human beta-globin locus control regions (LCR). The HS I-V betaS transgene expresses a glutamic acid to valine mutation of the human hemoglobin beta chain complex (HBB) that has been linked to sickle cell disease. The HS I-V alpha transgene expresses a human alpha1 globin (HBA1) gene. Line 1 was generated. |
