| First Author | Lanfray D | Year | 2016 |
| Journal | Elife | Volume | 5 |
| PubMed ID | 26880548 | Mgi Jnum | J:269737 |
| Mgi Id | MGI:6208323 | Doi | 10.7554/eLife.11742 |
| Citation | Lanfray D, et al. (2016) Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice. Elife 5:e11742 |
| abstractText | Acyl-CoA binding domain-containing 7 (Acbd7) is a paralog gene of the diazepam-binding inhibitor/Acyl-CoA binding protein in which single nucleotide polymorphism has recently been associated with obesity in humans. In this report, we provide converging evidence indicating that a splice variant isoform of the Acbd7 mRNA is expressed and translated by some POMC and GABAergic-neurons in the hypothalamic arcuate nucleus (ARC). We have demonstrated that the ARC ACBD7 isoform was produced and processed into a bioactive peptide referred to as nonadecaneuropeptide (NDN) in response to catabolic signals. We have characterized NDN as a potent anorexigenic signal acting through an uncharacterized endozepine G protein-coupled receptor and subsequently via the melanocortin system. Our results suggest that ACBD7-producing neurons participate in the hypothalamic leptin signalling pathway. Taken together, these data suggest that ACBD7-producing neurons are involved in the hypothalamic control exerted on food intake and energy expenditure by the leptin-melanocortin pathway. |
