| First Author | Arthurs JW | Year | 2023 |
| Journal | Neuroscience | Volume | 517 |
| Pages | 105-116 | PubMed ID | 36898496 |
| Mgi Jnum | J:352434 | Mgi Id | MGI:7448242 |
| Doi | 10.1016/j.neuroscience.2023.03.003 | Citation | Arthurs JW, et al. (2023) Activation of Parabrachial Tachykinin 1 Neurons Counteracts Some Behaviors Mediated by Parabrachial Calcitonin Gene-related Peptide Neurons. Neuroscience 517:105-116 |
| abstractText | Many threats activate parabrachial neurons expressing calcitonin gene-related peptide (CGRP(PBN)) which transmit alarm signals to forebrain regions. Most CGRP(PBN) neurons also express tachykinin 1 (Tac1), but there are also Tac1-expressing neurons in the PBN that do not express CGRP (Tac1+;CGRP- neurons). Chemogenetic or optogenetic activation of all Tac1(PBN) neurons in mice elicited many physiological/behavioral responses resembling the activation of CGRP(PBN) neurons, e.g., anorexia, jumping on a hot plate, avoidance of photostimulation; however, two key responses opposed activation of CGRP(PBN) neurons. Activating Tac1(PBN) neurons did not produce conditioned taste aversion and it elicited dynamic escape behaviors rather than freezing. Activating Tac1+;CGRP- neurons, using an intersectional genetic targeting approach, resembles activating all Tac1(PBN) neurons. These results reveal that activation of Tac1+;CGRP- neurons can suppress some functions attributed to the CGRP(PBN) neurons, which provides a mechanism to bias behavioral responses to threats. |
