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Allele : Tg(Thy1-APPSweLon)41Ema transgene insertion 41, Eliezer Masliah
Primary Identifier  MGI:5491622 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(Thy1-APPSweLon)41Ema
Strain of Origin  (C57BL/6 x DBA/2)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  The murine Thy1 promoter drives expression of the hAPP751 cDNA containing the Swedish (K670N/M671L) and the London (V717I) mutations. Immunohistochemistry confirmed high expression of human APP in the neocortex and hippocampus and moderate expression in the thalamus, basal ganglia, and cerebellum. Three lines were made, 16, 11, and 41. Line 41 is the highest expressing line.
  • mutations:
  • Insertion
  • synonyms:
  • Tg(Thy1-APP*K670N*M671L*V717I)41Ema,
  • Tg(Thy1-APP*K670N*M671L*V717I)41Ema,
  • mThy1-hAPP751,
  • T41 APP,
  • APP41,
  • T41 APP,
  • TASD41,
  • mThy1-hAPP751,
  • APP41,
  • Tg(Thy1-APP*Swe*Lon)41Ema,
  • TASD41,
  • Tg(Thy1-APP*Swe*Lon)41Ema
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

38 Publication categories





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