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Allele : Tg(tetO-MAML1*/EGFP)2Akar transgene insertion 2, Aly Karsan
Primary Identifier  MGI:5496022 Allele Type  Transgenic
Attribute String  Dominant negative, Inducible, Inserted expressed sequence, Reporter Gene  Tg(tetO-MAML1*/EGFP)2Akar
Strain of Origin  ICR Induced With  doxycycline/tetracycline
Is Recombinase  false Is Wild Type  false
molecularNote  The Tet-dnMAML-GFP transgene was designed with a TetOS promoter followed by a cDNA sequence encoding the dnMAML-GFP fusion protein and an SV40 polyA sequence. The TetOS promoter (Tet response element or TRE) contains seven copies of the 42-bp tet operator sequence (tetO) just upstream of a minimal CMV promoter. The dnMAML-GFP cDNA sequence encodes an N-terminal, 62 amino acid (amino acids 13-74), a dominant-negative mutant variant of human Mastermind-like 1 (dnMAML) fused in-frame at its C-terminus to an enhanced green fluorescent protein (EGFP).
  • mutations:
  • Insertion
  • synonyms:
  • Tet<OS>-dnMAML-GFP,
  • dnMAML-GFP,
  • Tet<OS>-dnMAML-GFP,
  • TetOS-dnMAML,
  • dnMAML-GFP,
  • TetOS-dnMAML
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

6 Publication categories





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