| Primary Identifier | MGI:5494696 | Allele Type | Targeted |
| Attribute String | Conditional ready, Constitutively active, Humanized sequence, Inserted expressed sequence, Reporter | Gene | Gt(ROSA)26Sor |
| Transmission | Germline | Strain of Origin | B6.Cg-Thy1<a> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The CAG promoter drives ubiquitous expression of a fusion of human MAP2K7 containing the constitutively activating mutations aspartic acid for serine and threonine at positions 271 and 275, respectively (S271D and T275D) and MAPK8 followed by an FRT-flanked IRES sequence and EGFP gene. A floxed neomycin resistance and STOP cassette prevents expression of the fusion product until cre-mediated removal. |
