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Allele : Gt(ROSA)26Sor<tm1(CAG-MAP2K7*/MAPK8,-EGFP)Ftw> gene trap ROSA 26, Philippe Soriano; targeted mutation 1, F Thomas Wunderlich
Primary Identifier  MGI:5494696 Allele Type  Targeted
Attribute String  Conditional ready, Constitutively active, Humanized sequence, Inserted expressed sequence, Reporter Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  B6.Cg-Thy1<a>
Is Recombinase  false Is Wild Type  false
molecularNote  The CAG promoter drives ubiquitous expression of a fusion of human MAP2K7 containing the constitutively activating mutations aspartic acid for serine and threonine at positions 271 and 275, respectively (S271D and T275D) and MAPK8 followed by an FRT-flanked IRES sequence and EGFP gene. A floxed neomycin resistance and STOP cassette prevents expression of the fusion product until cre-mediated removal.
  • mutations:
  • Insertion
  • synonyms:
  • JNK<C>,
  • ROSA JNK<C>,
  • JNK<C>,
  • ROSA JNK<C>
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1 Feature

Trail: Allele

Genome

2 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

6 Publication categories

Trail: Allele




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